【摘要】 目的　探讨甾醇调节因子结合蛋白裂解激活蛋白 (SCAP)基因 Ile796Val多态性与缺血性心脑血管疾病患者的相关性。方法　选取冠心病患者 1 1 2例分为 2组〔血清胆固醇 (TC)与甘油三酯 (TG)正常组 50例 ,血清 TC与 TG增高组 62例〕,缺血性脑卒中患者 53例。采用 PCR-RFLP的分析方法 ,检测老年人群中缺血性心脑血管疾病患者 SCAP基因 Ile796Val的多态性。结果　冠心病血脂正常组与对照组相比 ,基因型和等位基因差异无显著性 (P>0 .0 5)。冠心病血脂增高组和缺血性脑卒中组与对照组相比 ,基因型和等位基因均有显著性差异 (P<0 .0 5) ,且 A等位基因频率显著高于对照组。结论　 SCAP基因 Ile796Val多态性对心脑血管的遗传学研究具有重要意义。提示 SCAP基因 A等位基因与动脉粥样硬化有着密切的关系 ,并且增加了罹患缺血性心脑血管疾病的风险性。更多还原

【Abstract】 Objective To investigate the relationship between ischemic cerebral and heart diseases and the Ile796Val polymorphism of human SCAP gene. Methods Patients with coronary heart disease (n=112) were divided into 2 groups according to the serum levels of cholesterol (TC) and triglycerin (TG) 〔GroupⅠ(n=50) with normal values and groupⅡ(n=62) with increased TC and TG〕, and there were 53 patients with ischemic cerebral stroke. Using PCR-RFLP, we detected the genotype of the SCAP gene Ile796Val polymorphism of CHD, ischemic cerebral stroke and normal controls. Results The difference of genotypes and alleles between groupⅠ and control group was not significantly (P<0.05). But there were significant differences in frequencies of genotype and alleles in groupⅡand ischemic cerebral stroke group compared with the controls. The A allele frequencies of SCAP gene in the ischemic cerebral and heart diseases were higher than those in controls. Conclusions A Ile796Val polymorphism of human SCAP gene may cause disorders of lipid metabolism in patients with ischemic cerebral and heart diseases. The A allele of Ile796Val polymorphism of human SCAP gene may be related to atherosclerosis and increase the fatalness of suffering from ischemic cerebral and heart diseases.更多还原