【摘要】 以红霉素 A为原料 ,与水合肼缩合后 ,经重氮化 /硼氢化钠还原制得 (9S) -红霉胺 ,再与 2 - (2 -甲氧乙氧基 )乙醛缩合 ,精制后得到地红霉素 ,总收率 37%。本制备工艺立体选择性高、反应条件温和、适合工业化生产更多还原

【Abstract】 Dirithromycin was synthesized by condensation of erythromycin A with hydrazine hydrate, reduced by sodium borohydride, then condensation with 2-(2-methoxyethoxy) acetaldehyde and purification, the overall yield was 37%. This method has the advantage of higher stereoselectivity, milder reaction condition, and can be used to prepare dirithromycin in industrial scale.更多还原