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膀胱肿瘤6号染色体长臂的杂合性缺失研究
Loss of heterozygosity of microsatellite DNA on 6q in bladder tumor
【摘要】 目的探讨 6号染色体长臂的杂合性缺失 (LOH)与膀胱肿瘤的关系。方法应用 6q2 1区域附近D6S40 4、D6S43 4微卫星标志 ,以PCR SSLP 银染法对 3 1例膀胱肿瘤患者的肿瘤组织进行杂合性缺失的研究。结果膀胱肿瘤组织D6S40 4LOH发生率为 3 5 5 %,D6S43 4LOH发生率为 2 2 6%。结论 6q2 1区域附近可能存在与膀胱肿瘤相关的肿瘤抑制基因。
【Abstract】 ObjectiveTo investigate the loss of heterozygosity (LOH) on 6q in bladder tumor.MethodsD6S404 and D6434 microsatellite markers near 6q21 were tested by PCR-SSLP-stain method on tumor DNA from 31 cases of bladder tumor.ResultsAmong these 31 cases of bladder tumor,LOH was detected in tumor tissues on site for D6S404 (35.5%) and D6S434(22.6%).ConclusionOne or more tumor suppressor gene near 6q21 maybe relevant for the development of bladder tumor.
【关键词】 膀胱肿瘤；
杂合性缺失；
6号染色体长臂(6q)；
【Key words】 bladder tumor； loss of heterozygosity (LOH)； long arm of chromosome 6(6q)；
【Key words】 bladder tumor； loss of heterozygosity (LOH)； long arm of chromosome 6(6q)；
- 【文献出处】 中国康复理论与实践 ,Chinese Journal of Rehabilitation Theory & Practice , 编辑部邮箱 ,2004年05期
- 【分类号】R737.14
- 【下载频次】42