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热休克蛋白27在乳腺癌中的表达及意义
The Study on Expression of HSP27 in Human Breast Carcinoma
【摘要】 目的 :研究热休克蛋白 2 7(HeatShockProtein2 7)在乳腺癌中的表达。方法 :采用免疫组化方法检测 4 8例乳腺癌组织中的HSP2 7。结果 :HSP2 7在乳腺癌中阳性表达率为 5 4.17%(2 6 / 4 8)。在非浸润性癌和浸润性癌中阳性表达率为 75 .0 0 % (3/ 4 )和 5 2 .2 7% (2 3/ 4 4 )。HSP2 7阳性表达在非浸润性癌和浸润性癌中无明显差别 (P >0 .0 5 )。HSP2 7阳性表达与有无淋巴结转移无关 (P >0 .0 5 )。结论 :在乳腺癌中HSP2 7有较高表达 ,检测乳腺癌中HSP2 7对化疗有指导作用
【Abstract】 Objective: To study the experssion of HSP 27 in the breast carcinoma. Methods: Immunohistochemistry is used to detect the expression of HSP 27 in the breast carcinoma(n=48).Results: The positive rate of HSP 27 in the breast carcinoma was 54.17%(26/48), and the positive rate of HSP 27 in the non-infiltrative carcinoma and the infiltrative carcinoma was 75.00%(3/4)and52.27%(24/44), respectively, there was no significant difference in the level of expression of HSP 27 between the non-infiltrative carcinoma and the infiltrative carcinoma(P>0.05). The expression of HSP 27 bore no relation to lymph nodes matastasis of breast carcinoma. Conclusion: The positive rate of HSP 27 is high in breast carcinoma and clinically has an important guiding significance in the chemotherapy serategy.
【Key words】 breast carcinoma; immunohisochemistry; heat shock protein 27;
- 【文献出处】 张家口医学院学报 ,Journal of Zhangjiakou Medical Collage , 编辑部邮箱 ,2004年01期
- 【分类号】R737.9
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