【摘要】 目的　探讨中毒性疾病血浆神经肽〔β -内啡肽 ( β-EP)、神经肽Y(NPY)、神经降压素 (NT)〕含量变化的关系。方法　采用放射免疫测定法 (RIA)分别检测 4 6例急性中毒性疾病 (海洛因中毒 16例、镇静类药物中毒 16例、有机磷中毒 14例 )入院时、第 6小时、第 2 4小时 3种神经肽血浆中的含量变化 ,并设相应对照组。结果　中毒性疾病的血浆 β -EP、NPY、NT含量显著升高。中毒性疾病在急性期血浆神经肽水平最高 ,第 6小时以后逐渐降低。结论　血浆神经肽与急性中毒性疾病的发病、转归关系密切 ,直接参与疾病的病理过程 ,对疾病的观察、治疗具有重要意义更多还原

【Abstract】 Objective To study plasma neuropeptide(β-EP,NPY,NT) levels dynamic change in acute toxic diseases. Methods The concentration of neuropeptides(β-EP, NPY, NT) were measured by radioimmunoassay(RIA)in 46 patients with acute toxic diseases (16 cases with acute heroin poisoning, 16 hypnotics poisoning and 14 acute organo-phosphorus poisoning) at 0,6,24 hours after onset Results β-EP, NPT and NT levels in patients were significantly higher than those in controls(P<0.01).β-EP,NPT and NT levels gradually lowered after 6 hours.Conclusion Plasma neuropeptide levels might play an important role in acute toxic diseases and the levels might be useful clinical guide to treatment.更多还原