【摘要】 目的　探讨慢性阻塞性肺疾病 (COPD)急性加重期患者血清免疫球蛋白的水平及其临床意义。方法　COPD急性加重期 4 4例和正常健康对照组 30例均取清晨空腹静脉血测定其血清免疫球蛋白 (IgM、IgA、IgG)的水平 ,并比较两组之间有无差异。 结果　COPD急性加重期患者血清免疫球蛋白的水平分别为 :IgM (1 70± 0 6 7) g/L、IgA (2 5 3± 1 2 7)g/L、IgG (11 86± 3 78) g/L ;正常健康对照组血清免疫球蛋白的水平分别为 :IgM (1 92± 0 76 )g/L、IgA (1 71± 0 6 8) g/L、IgG (11 12± 2 72 ) g/L。两组比较 ,IgM、IgG的水平差异无显著意义 (P >0 0 5 ) ,而IgA的水平差异有显著意义 (P <0 0 1)。 结论　COPD急性加重期患者血清IgA水平的升高可能与呼吸道感染有关。更多还原

【Abstract】 Objective To study the level and clinical significance of immunoglobulin in acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods We detected the level of sera immunoglobulin(IgM,IgA,IgG)in 44 cases of AECOPD and 30 normal controls,and compared their differences.Results The levels of sera immunoglobulin(IgM,IgA,IgG) in 44 cases of AECOPD were respectively (1.70±0.67)g/L,(2.53±1.27)g/L,(11.86±3.78)g/L,in 30 normal controls were respectively (1.92±0.76)g/L,(1.71±0.68)g/L,(11.12±2.72)g/L.There was no significant difference between the levels of sera IgM and IgG in 44 cases of AECOPD and 30 normal controls(P>0.05),but the level of IgA in 44 AECOPD was significantly higher than that of 30 normal controls(P<0.01).Conclusion The high serum IgA in AECOPD is correlative to infection in respiratory tract.更多还原