【摘要】 目的　比较肝硬化患者血浆内皮素 1(ET 1) ,肿瘤坏死因子 α(TNF α)、透明质酸 (HA)、Ⅳ型胶原 (Ⅳ·C)含量变化 ,并探讨其与食管静脉曲张的关系。方法　采用放免法分组检测 6 0例肝硬化患者及 2 0例正常人ET 1、TNF α、Ⅳ·C和HA水平。结果　肝硬化组ET 1、TNF α、HA和Ⅳ·C含量均高于正常对照组(P <0 0 5～ 0 0 1) ,肝硬化ChildC级均高于ChildB级和ChildA级 ,Child分级与ET 1、TNF α、HA和Ⅳ·C含量呈正相关 (r=0 6 4 ,r =0 5 7,r =0 6 9;P <0 0 5 ) ;食管静脉曲张患者ET 1、TNF α、HA和Ⅳ·C含量均高于无食管静脉曲张者 ,并随食管静脉曲张严重程度而上升。结论　肝硬化患者ET 1、TNF α、HA和Ⅳ·C含量检测对了解肝硬化程度有帮助。更多还原

【Abstract】 Objective To compare the contents of endothelin-1(ET-1),tumor necrosis factor-α(TNF-α),hyaluronic aid(HA) and collagen type Ⅳ(Ⅳ·C) in patients with hepatocirrhosis.Methods The contents of ET-1,TNF-α,HA and Ⅳ·C were measured by radioimmunoassy in hepatocirrhosis(n=60) and normal controls(n=20).Results The contents of ET-1,TNF-α,HA and Ⅳ·C increased significantly in disease group as compared with those the normal controls(P<0.01).The contents of ET-1,TNF-α,HA and Ⅳ·C in Child C were higher than those in Child A and Child B in patients with hepatocirrhosis.The contents of ET-1,TNF-α,HA, Ⅳ·C and Child grade were positive associated(r=0.64,r=0.57,r=0.69;P<0.05).The contents of ET-1,TNF-α,HA,Ⅳ·C in esophagus varix were higher than those in non-esophagus varix.The contents were rised along with the severity degree of the disease.Conclusion The change of contents of ET-1,TNF-α,HA and Ⅳ·C could reflect the disease condition in patients with hepatocirrhosis.更多还原