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MMP9和CD44V6表达与大肠腺癌浸润转移的关系

The relationship between the expression of MMP9 and CD44V6 and the invasion and metastasis of large intestine adenocarcinoma

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【作者】 钟良清罗爱华曾洲红朱秀梅罗卫

【Author】 ZHONG Liangqing,LUO Aihua,ZEN Zouhong,et al.Department of Pathology,Gaozhou City People’s Hospital,Guangdong,525200,China

【机构】 广东高州市人民医院病理科广东高州市人民医院病理科 525200525200

【摘要】 目的 探讨MMP9和CD44V6在大肠癌中的表达与大肠腺癌术后是否复发的关系。方法 应用免疫组化技术 ,检测 12 8例大肠腺癌组织中MMP9和CD44V6的表达。结果  12 8例大肠腺癌中MMP9、CD44V6表达的阳性标记与大肠腺癌分级、浆膜浸润、淋巴结转移有相关性。结论 MMP9和CD44V6联合表达与大肠腺癌浸润转移密切相关。检测MMP9和CD44V6表达可作为判断大肠腺癌预后的客观指标。

【Abstract】 Objective To discuss the relationship between the expression of MMP 9 and CD 44V6 in the large intestine adenocarcinoma and the recurrence of large intestine adenocarcinoma.Methods The expression of MMP 9 and CD 44V6 in 128 cases of large intestine adenocarcinoma was detected immunohistochemically.Results The expression of MMP 9 and CD 44V6 was related to the grading,invasion and lymph node metastasis.Conclusion The combined expression of MMP 9 and CD 44V6 is associated with the invasion and metastasis of large intestine adenocarcinoma.The detection of MMP 9 and CD 44V6 can indicate the prognosis of large intestine adenocarcinoma.

【关键词】 大肠腺癌MMP9CD44V6
【Key words】 Large intestine adenocarcinoma MMP 9 CD 44V6
  • 【文献出处】 中国基层医药 ,Chinese Journal of Primary Medicine Pharmacy , 编辑部邮箱 ,2004年05期
  • 【分类号】R735.3
  • 【下载频次】57
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