【摘要】 目的　探索哌拉西林 /他唑巴坦 (TZP)经验治疗神经内科严重感染的疗效和安全性。方法　前瞻性治疗神经内科严重感染住院患者 ;TZP 4 5 g静滴q8h～q12h ,疗程 5～ 10d ,化脓性脑膜炎延长至 14d ;用药前后查血尿常规、肝肾功能 ,细菌培养加药敏。结果　临床有效率 88 1% ,治疗过程未发现TZP严重不良反应。结论　TZP在治疗神经内科严重感染是一种抗菌谱广、适用范围大、安全高效的抗菌药物 ,可作为神经内科严重感染经验治疗的首选药物之一更多还原

【Abstract】 OBJECTIVE To observe the efficacy and safety of piperacillin/tazobactam (Tazocin,TZP) in empiric treatment against severe infections in neurologic department. METHODS Four cases were diagnosed with purulent meningitis and 38 cases with pulmonary infection(3 cases combined with severe urinary infection,1 case with decubitus ulcers in the mean time) among 42 inpatients with severe infections in neurologic department which were treated prospectively. TZP were given 4 5 g, q8h q12h, iv for 5 10d (purulent meningitis for 14 d ). Examinations such as blood and urinary analysis, hepatic and renal functions, bacterium culture and sensitivity tests were done before and after the treatment. RESULTS The total efficacious rate was 88 1% (37/42). No severe adverse reactions were found. CONCLUSIONS TZP is an antibiotic agent with a broad spectrum, wide range of suitability, safty and high efficacy in the therapy of severe infections in neurologic department. It can be one of the drugs of choise suitable for empiric use in severe infections in neurologic department.更多还原