【摘要】 目的　研究前房植入环孢素A缓释系统 (CsADDS)的生物相容性和房水药物浓度变化。方法　新西兰白兔 36只 ,随机分为A、B、C、D四组 ,分别与A、B、C、D四型不同的CsADDS相对应。每组 9只兔随机编号为 1～ 9号 ,其中 1～ 3号兔各任选 1只眼前房植入相应的CsADDS ,另 1只眼植入不含CsA的空白缓释系统 (EMDDS)为对照 ;4～ 6号兔各任选 1只眼前房植入EMDDS ,另 1只眼行角膜切开及缝合术为对照 ;7～ 9号兔各任选 1只眼前房植入CsADDS ,另 1只眼行角膜切开及缝合术为对照。术后观察 12周。结果　四型CsADDS均未见明显眼内毒性反应 ;A、B两型释药速率迅速 ,但维持时间短 ,C、D两型则缓慢而持久。结论　前房植入CsADDS对兔眼的生物相容性良好 ;4型CsADDS中A、B型较适宜治疗排斥反应 ,C、D型较适宜预防排斥反应。更多还原

【Abstract】 Objective To study the drug concentration in the aqueous humor and the biocompatibility of cyclosporine A drug delivery system (CsA DDS) implanting in the anterior chamber. Methods There were four different types of CsA DDS which had different biodegradable polymers as the vector or had different ratio between CsA and the vector. Thirty-six New Zealand rabbits were randomly divided into 4 groups to receive the 4 different types of CsA DDS. Three of nine New Zealand rabbits received CsA DDS in one eye and empty DDS in the contralateral eye. Three rabbits received empty DDS in one eye and keratotomy in the contralateral eye. Another three rabbits received CsA DDS in one eye and keratotomy in the contralateral eye. All DDS were implanted into the anterior chamber. The follow-up period was 12 weeks. Results No significantly acute or chronic intraocular toxic effects were found in all groups. The CsA release rate was different in these 4 groups. In type Α and B CsA DDS, the drug released fast and maintained for a short period; in type C and D, the drug released slowly and could be maintained for a long period. Conclusion CsA DDS implanted in the anterior chamber can be well tolerated in rabbit eyes. CsA DDS is a promising approach for the prevention (type C and D CsA DDS) and treatment (type A and B CsA DDS) of corneal graft rejection.更多还原