【摘要】 目的　总结国内报道的 15例胰腺血管活性肠肽瘤 (VIPoma)的临床资料 ,探讨VIPoma的诊断和治疗方法。方法　报告本院 2 0 0 2年收治的 1例VIPoma ,并检索 1987年 1月～ 2 0 0 2年 12月国内文献 ,取其中资料较完整的 14例VIPoma ,包括本院 1例共 15例VIPoma ,对其临床表现、实验室检查、影像学检查、手术方式、病理学检查和随访资料进行临床分析。结果　周期性发作的分泌性腹泻、低钾血症、无胃酸或低胃酸分泌是VIPoma主要临床表现 ,本院诊治的 1例还表现为周期性腰背部疼痛、皮疹和结肠多发腺瘤性息肉 ;免疫组化染色包括胰腺血管活性肠肽 (VIP)在内的多种消化道激素表达呈阳性 ;经手术治疗后 ,临床症状及水样泻消失 (结肠多发腺瘤性息肉除外 ) ,血浆VIP明显下降。本院 1例合并切除VIPoma侵犯的肠系膜上静脉。结论　VIPoma的诊断依赖于典型的临床症状和血浆VIP测定 ;手术切除是最有效的治疗手段 ;对于肝转移者可采用手术切除、射频消融、肝移植等方法治疗。更多还原

【Abstract】 ObjectiveTo discuss the experiences of diagnosis and treatment for vasoactive intestinal peptide-secrating-tumors (VIPoma) by summarizing clinical informations of 15 patiens with VIPoma. MethodsTo analyze Clinical manifestations?laboratory examinations?imaging features?operation?pathological findings and follow up survey of 15 patients,among them 1 case from our hospital and the other 14 cases were serched in chinese biological and medical literature database from Jan 1987 to Dec 2002. ResultsThe main clinical manifestation include periodical secreatory watery diarrhea?hypokalemia?achlorhydria,in addition,periodical backache ?skin rash ?and polyps of colon were presented in the case in our hospital. The immunohistochemical expression of many kinds of digestive hormone including VIP presented positive;All clinical symptoms of which except polyps disappeared after operation,elevated VIP data in serum also markedly decreased. Part resection of superior mesenteric vein was performed in the same patient. ConclusionsVIPoma is rare. Typical sympotoms and the serum value of VIP were keys to diagnosis,the operation is the most effective means for treatment. Resection of tumor,Radiofrequency tissue ablation ,liver transplantation can be selected for metastatic VIPoma in the liver.更多还原