【摘要】 目的　检测正常肝脏、慢性肝炎、肝硬化、肝细胞癌组织中COX 2基因的表达 ,并分析COX 2基因在肝细胞癌中表达的临床意义。方法　利用免疫组织化学方法检测 110例肝细胞癌组织中COX 2基因的表达 ,并以 5例正常肝组织 ,12例慢性乙型肝炎组织 ,15例肝硬化组织为对照 ,比较其中COX 2基因表达的差异。结果　正常肝组织、慢性肝炎组织、肝硬化组织、肝细胞癌组织中COX 2的表达率分别为 0 %、3 3 .3 %、46.7%和 64 .7% ,肝细胞癌组织中的表达明显上调 ,且呈“不表达 中度表达 高表达”之势。结论　COX 2基因在肝炎 肝硬化 肝癌的演变过程中起着某种作用 ,参与了肝细胞癌发生、发展、侵袭、转移的全过程。更多还原

【Abstract】 Objective To clarify the significance of cyclooxygenase-2 (COX-2) expression in normal liver,chronic hepatitis,cirrhosis tissues and primary hepatocellular carcinoma.Methods By using immunohistochemistry,the expression of Cox-2 was detected in the cancerous tissues of 110 patients with primary hepatocellular carcinoma and compared with that in normal liver tissues of 5 cases,liver tissues of 12 patients with chronic hepatitis B and 15 patients with cirrhosis.Results The Cox-2 expression rate was 0,33.3%,46.7% and 64.7% in the normal liver tissue and the liver tissues of chronic hepatitis B,cirrhosis and primary hepatocellular carcinoma,respectively.The expression of Cox-2 presented a trend of “no expression-middle expression-high expression”.Conclusion COX-2 may play a role in hepatocarcinogenesis from chronic hepatitis to cirrhosis to HCC and is involved in the whole progress of HCC.更多还原