【摘要】 目的　探讨急性脑卒中后抑郁状态 (PSD)与急性脑卒中发病时多种因素的相关性。方法　对 5 8例急性脑卒中患者使用汉密顿抑郁量表对抑郁程度评分 ,根据脑卒中脑神经功能缺损评分(NFD)标准对神经功能进行评分 ,计算IgG指数 ,测定脑脊液内一氧化氮 (NO)含量 ,进行卒中定位、定性 ,对所得结果进行单因素t检验和 χ2 检验 ,各因素之间做直线回归分析。结果　PSD发生率为2 9% ;脑卒中患者PSD发生率高于脑出血患者 (χ2 =4 86 ,P <0 0 5 ) ;PSD组IgG指数 (t =3 16 ,P <0 0 5 )、NO含量 (t=6 2 0 ,P <0 0 1)及NFD(t=2 35 ,P <0 0 5 )均高于非抑郁组 ;PSD组其他合并症较非抑郁组多 (t=2 74 ,P <0 0 5 ) ;IgG与NO呈正相关 (r =0 4 15 ,P <0 0 1)。结论　PSD是一种病态心理性改变 ,但它有确定的免疫病理生理性改变 ,检测这些因素对预测PSD有一定参考作用。更多还原

【Abstract】 Objective To investigate correlation between post-stroke depression (PSD) and multiple factors during onset of acute cerebral infarction. Methods Depression was measured with Hamilton Depression Rating Scales (HAMD) in 58 patients with acute cerebral infarction, and their neurological function were evaluated by neurological function defect (NFD) score. Their immunoglobulin G (IgG) index was calculated and level of nitric oxide (NO) in cerebrospinal fluid (CSF) was measured. Lesion and nature of cerebral infarction in 58 patients with acute stroke were located by CT. All the data were statistically analyzed with student-t test and χ 2 test, as well as linear regression model. Results Seventeen of 58 patients of stroke appeared PSD with an occurrence rate of 29.3%. Occurrence rate of PSD was significantly higher in patients with cerebral infarction than in those with cerebral hemorrhage  2=4.86, P<0.05). IgG index (t=3.16, P<0.05), CSF level of NO (t=6.20, P<0.01) and NFD (t=2.35, P<0.05) were all higher in those with PSD than in those without PSD. There was a positive correlation between IgG index and CSF level of NO (r=0.415, P<0.01). Conclusions PSD is a psychological change with definite immunological and pathophysiological basis. Examinations of relevant factors mentioned above can provide clues to predict occurrence of PSD.更多还原