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复痤霜中盐酸克林霉素和螺内酯的HPLC测定

Determination of Clindamycin Hydrochloride and Spironolactone in Compound Clindamycin Cream by HPLC

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【作者】 丁俊杰王蓓施孝金李中东钟明康

【Author】 DING Jun-Jie, WANG Bei, SHI Xiao-Jin, LI Zhong-Dong, ZHONG Ming-Kang(Division of Clinical Pharmacy Research, Huashan Hospital, Fudan University, Shanghai 200040)

【机构】 复旦大学附属华山医院临床药学研究室复旦大学附属华山医院临床药学研究室 上海200040上海200040上海200040

【摘要】 建立高效液相色谱法同时测定复痤霜中克林霉素和螺内酯的含量。采用C18柱,流动相为乙腈-磷酸盐缓冲液(pH7.4)(45∶55),检测波长214nm。克林霉素和螺内酯均在30~70靏/ml范围内线性关系良好(r>0.999),回收率大于98%,日内、日间RSD均小于2%。

【Abstract】 A HPLC method for simultaneous determination of clindamycin and spironolactone in compound clindamycincream was established. A C18 column was used with the mobile phase of acetonitrile-phosphate buffer solution(pH 7.4)(45∶55) at the detection wavelength of 214nm. The calibration curves of clindamycin and spironolactone were linear inthe concentration range of 30~70ìg/ml(r>0.999). The recoveries were more than 98%. The RSDs of intra- and inter-day were less than 2%.

  • 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2004年09期
  • 【分类号】TQ463
  • 【被引频次】6
  • 【下载频次】54
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