【摘要】 新型离子通道及镇痛机理的发现,为药学研究提供了大量镇痛新靶点,包括河豚毒抗性-Na+(TTXr-Na+)通道阻滞剂、N-型Ca2+通道阻滞剂、酸敏离子通道(ASICs)阻滞剂、烟碱型乙酰胆碱受体(nAChRs)激动剂、N-甲基-D-门冬氨酸(NMDA)受体拮抗剂、g-氨基丁酸A亚型(GABAA)受体激动剂、P2X受体拮抗剂和香草素受体(VR)调节剂。更多还原

【Abstract】 The discovery of novel classes of ion channels and their mechanisms of analgesia has provided pharma-ceutical researches with a large number of novel targets for pain therapy, including: tetrodotoxin-resistant (TTXr) Na+ ionchannel blockers, N-type Ca2+ ion channel blockers, acid-sensitive ion channel (ASICs) blockers, nicotinic acetylcholinereceptor (nAChRs) agonists, N-methyl-D- aspartate (NMDA) receptor antagonists, g-aminobutyric acid receptor subtypeA (GABAA) receptor agonists, P2X receptor antagonists and vanilloid receptor (VR) regulators.更多还原