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马来酸氯苯那敏中有机溶剂残留量的GC测定
Determination of Residual Organic Solvents in Chlorphenamine Maleate by GC
【摘要】 建立了毛细管气相色谱法测定马来酸氯苯那敏中的乙醇、丙酮、甲苯和DMF的含量。用CP-624色谱柱,柱温采取程序升温。各溶剂的线性关系良好(r均在0.99以上),平均回收率99.8%~101.2%。
【Abstract】 A capillary GC method for the determination of residual organic solvents——ethanol, acetone, tolueneand dimethylformamide in chlorphenamine maleate was established. A CP-624 column was used with procedural columntemperature control. The calibration curves of four solvents were linear (r>0.99). The average recoveries were 99.8%~101.2%.
【关键词】 马来酸氯苯那敏;
有机溶剂残留量;
毛细管气相色谱;
测定;
【Key words】 chlorphenamine maleate; residual organic solvent; capillary GC; determination;
【Key words】 chlorphenamine maleate; residual organic solvent; capillary GC; determination;
- 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2004年04期
- 【分类号】TQ463
- 【被引频次】3
- 【下载频次】127