【摘要】 7-氨基-3-乙烯基头孢烷酸和[(2-氨基-噻唑-4-基)-(苯并噻唑-2-基-硫基羰基)亚甲基氨基氧基]乙酸叔丁酯经酰胺化、水解等反应合成头孢克肟,总收率35.8％。更多还原

【Abstract】 Cefixime was synthesized by amidation and hydrolysis from [(2-amino-thiazol-4-yl)-(benzothiazol-2-yl-sulfanylcarbonyl) methyleneaminoxy]acetic acid f-butyl ester and 7-amino-3-vinylcephalosporanic acid in an overall yield of 35.8%.更多还原