【摘要】 目的　研究高场强电磁脉冲辐射对小鼠肝的损伤效应。方法　二级昆明小鼠 2 0 4只 ,分为对照组 ( 2 4只 )和辐射组 ( 180只 ) ,辐射组小鼠又根据照射剂量分为 8× 10 3 V/m、2× 10 4V/m和 6× 10 4V/m辐射亚组。对照组不作任何处理 ,辐射组采用高场强电磁脉冲 (EMP)源 ,分别对所有小鼠进行全身辐射 ,于辐射后 6h、1d、3d、7d、14d、1个月、3个月、6个月、9个月及 12个月观察不同场强电磁脉冲辐射对小鼠肝病理形态的影响 ,并与对照组 14d、3个月、6个月及 12个月进行比较。结果　辐射后小鼠肝病理改变呈进行性发展趋势 ,早期 ( 6h～ 3d)以肝实质细胞变性为主 ,中后期 ( 7d～ 1个月 )以肝细胞坏死为重 ,晚期 ( 3～ 12个月 )肝细胞增生活跃 ,可见非典型性增生与癌肿。结论　电磁辐射对小鼠肝具有损伤效应 ,尤其对肝实质细胞损伤严重 ,且远后效应显著。更多还原

【Abstract】 Objective To investigate the effects of high power electromagnetic pulse field on pathological changes in the liver of mice. MethodsTwo hundred and four male Kunming mice were divided into a control group and an irradiation group, which was subdivided into 8×10 3V/m irradiation group, 2×10 4V/m irradiation group and 6×10 4V/m irradiation group according to the irradiation dosage. The mice in control group were given no irradiation. The mice in irradiation groups were irradiated with different dosages of high power electromagnetic pulse(EMP)respectively. Pathological changes of liver of the rats in respective irradiation groups were investigated at 6h, 1d, 3d, 7d, 14d, 1 month, 3 months, 6 months, 9 months and 12 months after irradiation,and compared with the control group at 14d, 3 months, 6 months, and 12 months after irradiation. ResultsPathological changes in the liver of mice developed progressively after irradiation. The degeneration of liver parenchymal cells were mainly observed at the early stage (6h～3d), the necrosis of hepatocytes were serious at the medium-to-late stage (7d～1 months), and at the late stage (3～12 months) the hyperplasia was active, even atypical hyperplasia and neoplasm can be found. ConclusionThe high power electromagnetic irradiation has injurious effect on liver of mice, especially on the liver parenchymal cells.更多还原