【摘要】 目的　我们首次采集 1例志愿者残肢的神经电信号以研究利用神经信息控制假肢模拟装置的可能性及可行性。方法　将自制神经束内电极分别直接插入患者残肢上臂桡、尺及正中神经的神经束内 ,电极远端连接 7自由度神经信息控制假肢模拟装置 ,以神经束外电极作参考电极。患者经过相关训练后 ,嘱其在清醒状态下用脑意识控制患侧作假想的指伸、屈动作 ,并观察模拟假肢装置的反应。结果　当患者用脑意识控制患侧作各种假想动作时 ,我们发现从桡神经导出的神经信息能够成功地触发假肢模拟装置作伸指动作 ,但无法实现闭合。从其它神经导出的信息均未能有效驱动假肢装置发生动作。从同一神经内的两个神经束内电极引出的神经信息亦未能有效驱动假肢装置发生动作。结论　神经束内电极可为神经信息控制假肢模拟装置提供残肢神经信息 ,但还需更深入地研究更多还原

【Abstract】 Objective To study the applicability of a prosthesis simulating instrument controlled by the nerve signals recorded from t he amputation stump of a human subject. Methods The s elf-made intrafascicular electrodes were inserted directly into the fasciculus of the three major nerves in the amputation stump of the upper arm. All distal e nds of the electrodes were connected with a 7 multidimension freedom nerve-sign al controlled prosthesis simulating instrument. An electrode was placed outside of the fasciculus as a reference electrode. When the patient was requested to ex ert finger-extension and finger-flexion in mind, reactions of prosthesis were observed. Results As the patient exerted the actions in mind, finger-extension of the prosthesis could be triggered by signal of ele ctrode in radial nerve and reference electrode, but finger-flexion was not obse rved. The signals of other two major nerve could not trigger any reaction of the prosthesis instrument. The signals recorded from two different fasciculus in the same never did not affect the instrument. Conclusion Intrafascicular electrodes could be used to record and provide nerve signals in amputation stump for the nerve-signal controlled prosthesis simulating inst rument.更多还原