【摘要】 目的 探讨细胞黏附分子在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压(HT)发病中的作用。方法 应用酶联免疫吸附测定(ELISA)方法检测30例OSAHS血压正常患者(OSAHS组)、30例OSAHS合并高血压患者(OSAHS+HT组)及30名健康者(正常对照组)血清中可溶性胞间黏附分子1(ICAM-1)、血管细胞黏附分子1(VCAM-1)和L-选择素的含量。结果 OSAHS+HT组及OSAHS组患者血清可溶性ICAM-1[分别为(601±406)μg/,L、(513±244)μg/L]、VCAM-1含量[分别为(578±176)μg/L、(480±144)μg/L]均明显高于正常对照组[分别为(355±119)μg/L、(310±163)μg/L,q值分别为4.78,3.07;9.09,5.76,P<0.01],差异有显著性;而L-选择素与对照组相比,差异无显著性(P>0.05);OSAHS+HT组的VCAM-1明显高于OSAHS组(q值为3.32,P<0.05),差异有显著性;ICAM-1水平与睡眠呼吸暂停低通气指数(AHI)及微觉醒指数呈明显的正相关(r=0.465,P<0.01,r=0.226,P<0.05);与最低血氧饱和度呈明显的负相关(r=-0.368,P<0.01)。结论 血清ICAM-1、VCAM-1水平的升高是OSAHS患者高血压发病的重要危险因子之一。更多还原

【Abstract】 Objective To explore the role of adhesion molecules in the pathogenesis of hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS) . Methods The levels of serum soluble intercellular adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1) and L-selectin in 30 OSAHS patients accompanied by hypertension, 30 normotensive OSAHS patients and 30 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA) method. The relationship of the concentration of ICAM-1, VCAM-1 and L-selectin with the polysomnogram (PSG) parameters was analyzed. Results The levels of serum soluble ICAM-1 [(601±406) μg/L, (513±244) μg/L, respectively] and VCAM-1 [(578±176) μg/L, (480±144) μg/L, respectively] were significantly higher in OSAHS accompanied by hypertension and normotensive OSAHS than those in the healthy controls[(355±119)μg/L, (310±163)μg/L,9=4. 78,3.07;9. 09,5.76,P <0. 01,respectively]. But the levels of serum L-selectin was not significantly different among the three groups (P>0.05) . The levels of serum VCAM-1 were significantly higher in OSAHS accompanied by hypertension than those in the normotensive OSAHS ( q = 3. 32 ,P < 0. 05 ) . The was not significantly different between the two groups ( P > 0. 05 ) . There was a significantly positive correlation between the concentration of ICAM-1 and the apnea hyponea index( AHI) as well as microarousal index in all the 60 OSAHS patients with and without hypertension ( r = 0. 465, P < 0. 01 , r =0. 226,P <0. 05). There was a significantly negative correlation between the concentration of ICAM-1 and the lowest oxygen desaturation in all the 60 OSAHS patients with and without hypertension ( r = -0. 368, P < 0. 01). Conclusion The high level of serum VCAM-1 and ICAM-1 is an important risk factor for the development of hypertension in OSAHS patients.更多还原