【摘要】 目的　肝癌自发性破裂是一种危险的出血性并发症 ,其发病机制不详。我们既往的免疫组化研究已首次证实了该病人中存在血管病变现象 ,本实验旨在通过电子显微镜对其血管壁进行超微结构检查 ,以进一步证实其血管病变。方法　 1995～ 1997年间 ,对 11例肝癌破裂病人的手术标本与同期随机选取的 11例肝癌非破裂病人手术标本 ,进行血管内皮细胞的透射电子显微镜检查。结果　 11例肿瘤破裂的病人中 ,有 9例病人的血管壁出现内皮细胞受损现象 ,包括 :血管内皮细胞发生细胞连接消失、窗口直径过大及伴有高蛋白合成征象。在肿瘤非破裂的病人中 ,上述血管受损现象仅在 2例病人中发现 ,二者相比有显著性差异 (P <0 0 5 )。结论　肝癌破裂病人中的血管内皮细胞存在通透性增加及高蛋白合成现象 ,其病变可能与肿瘤破裂有关。更多还原

【Abstract】 Objective To investigate the ultrastructure of vascular wall in patients with spontaneous rupture of hepatocellular carcinoma (HCC) to identify the vascular injury that had been reported in our previous papers. Methods Transmission electron microscopy was used to examine the specimens from 11 patients with ruptured HCC and 11 patients with non-ruptured HCC. Results Vascular injury characterized by less cell junctions, larger fenestration and signs of more protein synthesis in endothelial cells was seen in specimens from 9 of the 11 patients with ruptured HCC but only in those from 2 of the patients with non-ruptured HCC. There was significant difference between the 2 groups of patients (P<0.05). Conclusions The vascular injury might be related to the spontaneous rupture of HCC.更多还原