【摘要】 目的　探讨肝细胞癌 (HCC)中C erbB2基因扩增和表达与临床病理特征之间的关系。方法　应用差异PCR和免疫组化方法检测 4 2例HCC中C erbB2基因扩增和表达情况 ,分析它们与HCC临床病理特征的关系。结果　C erbB2扩增和表达与HBsAg、肿瘤大小、Edmondson分级、临床分期、肝硬化、肝外转移和复发有关 ,而与年龄、性别、AFP值、丙肝病毒感染、肿瘤结节数和肿瘤包膜无关。结论　C erbB2基因不仅参与了HCC的发生、发展 ,并可作为判断HCC预后的生物学指标。更多还原

【Abstract】 Objective To investigate the relationship between amplification and expression of C-erbB2 gene and clinicopathological features in hepatocellular carcinoma (HCC). Methods The amplification and expression of C-erbB2 gene were determined with differential PCR and immunohistochemistry in 42 patients with HCC. Results The amplification and expression of C-erbB2 gene was correlated to HBsAg, tumor size, Edmondson’s grade, clinical stage, hepatic cirrhosis, exo-liver metastasis and relapse but not age, sex, AFP, HCV infection, tumor nodule and fibrous capsule. Conclusions C-erbB2 gene not only participate in occurrence and development of HCC but also can be regarded as a biological marker to estimate the prognosis.更多还原