【摘要】 目的　探讨不同剂量的32 P胶体局部注射对小鼠H2 2移植瘤和区域淋巴结转移灶的治疗作用。方法　应用小鼠H2 2腹水型肝癌淋巴道转移模型 ,通过肿瘤组织局部给药 ,观察32 P胶体在模型小鼠移植瘤、区域淋巴结及全身各器官、组织内的分布。结果　32 P胶体局部给药后主要聚集在瘤体注射局部和区域淋巴结内 ,而在肝、脾、肺等脏器分布的活度较低。区域淋巴结聚集的活度随给药剂量增高而递增。治疗早期瘤体和窝淋巴结转移灶呈现局灶性坏死。后期移植瘤和区域淋巴结转移灶的瘤组织呈现出血、坏死。结论　32 P胶体瘤体给药可在局部富集 ,并可经淋巴道转运、聚集于区域淋巴结 ,对肿瘤组织和邻近的淋巴结转移灶具有明显的杀伤作用。更多还原

【Abstract】 Objective To study the anticancer effects and biodistribution of chromic 32 P phosphate colloid in mice with lymphatic metastasis of hepatoma after intratumoral injection. Methods Forty-eight Km mice with H22 ascites hepatoma were injected with 32 P colloid intratumorally .The distribution of 32 P in regional lymph nodes and other organs was observed dynamically,and its anticancer effectiveness was investigated in the tumor and regional lymph nodes. Results 32 P mainly remained in the tumor and regional lymph nodes,while the of 32 P organs,such as liver,spleen,lung ,only retained a mild activity. By histopathologic observation,neoplamic focis could be found in pad,right popliteal lymph node and groin lymph node ,and necrosis was seen in the tumor and its metastatic foci in right popliteal lymph node. On day 17 after 32 P treatment,the transplanted tumor focis necrosed thoroughly,and normal structure of regional lymph nodes disappeared ,which was replaced by necrotic tissue and hemorrhage. Conclusion The intratumoral administration of chromic [ 32 P] colloid could be used for treatment of the primary tumor,and lymphatic metastatic focus as well ,in order to produce obvious anticancer effects.更多还原