【摘要】 目的　探讨电离辐射对豚鼠鼻黏膜组织损伤的特点。方法　选用健康实验成年豚鼠6 0只随机分成照射组和对照组 ,照射组用医用直线加速器对其进行鼻部分次照射 ,每周 1次 ,每次5 0Gy ,共照射 3周 ,照射完毕后分别于 1d、1,2 ,4 ,10周、0 5年随机活杀动物各 5只 ,取中鼻甲前端黏膜 ,HE染色 ,扫描 ,透射电镜观察及显微图像分析测量。结果　照射组鼻黏膜的早期病理改变是急性炎症反应 ,4周时黏膜开始修复 ,修复直至 0 5年时基本结束 ,但大部分黏膜失去了正常的纤毛柱状上皮结构特点 ,纤毛覆盖率仅达 5 2 9% ,部分区域甚至代为鳞状上皮。结论　鼻黏膜损伤及晚期的鳞状上皮化生是放疗后功能障碍的病理学基础。更多还原

【Abstract】 Objective To study histopathological changs in nasal mucosa of guinea pigs following a series of irradiation. Methods A total of 60 healthy guinea pigs were divided into two groups randomly:the irradiation group ( n =30) and the control group ( n =30). The animals of the irradiation group were exposed nasally to linear accelerator X-rays at 5.0 Gy once a week for three weeks.At 1 d, 1 w, 2 w,4 w,10 w and half year after X-irradiation five animals per one group were sacrificed randomly,at each time point.Their middle nasal turbinate mucosa was observed under optical microscope and electron microscope,and were analysed by image analysis for histopathological transformation. Results In the irradiation group,the early histopathological transformation was acute inflammatory reaction, at the fourth week the mucosa began to repair,which ended at the sixth month.But after repaired,some parts of the repaired mucosa were lined with squamous epithelium instead of the normal nasal mucosa.The rate of the cilia-covered area was only 52.9% at the sixth month. Conclusion The nasal mucosa injury and the squamous metaplasia could form a pathological basis of dysfunction after irradiation. ;更多还原