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注射用柴胡挥发油脂质体制备工艺研究
Study on liposome prepration technique of Bupleurum chinense volatile oil for injection
【摘要】 目的 :探讨将柴胡挥发油制成注射用脂质体的制备工艺可行性。方法 :通过研究柴胡挥发油脂质体的处方组成、挥发油包封率、冻干可行性以及二者的指纹图谱变化。结果 :柴胡挥发油的包封率为 81.9%。经冷冻干燥后 ,脂质体中被包封挥发油的保留率为 88.6 %。结论 :将柴胡挥发油制备成注射用脂质体在制备工艺上是可行的。
【Abstract】 Objective:To study the prepration technique of the liposome of Bupleurum chinense volatile oil. Method: The composition,entrapement ratio of volatile oil,availability of freeze-drying and the changes of finger prints were studied. Result:Entrapement ratio reached 81.9%. After freeze-dried,the remaining ratio of the oil entraped in the liposome reached 88.6%. Conclusion: It is practicable to make B. chinense injection into freeze-dried liposome powder.
【关键词】 柴胡挥发油;
脂质体;
制备工艺;
冻干粉针;
【Key words】 volatile oil; liposome; prepration technique; freeze-dried powder for injection;
【Key words】 volatile oil; liposome; prepration technique; freeze-dried powder for injection;
- 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2004年06期
- 【分类号】TQ461
- 【被引频次】39
- 【下载频次】827