【摘要】 目的分析骨密度与心血管疾病各个危险因素之间有无相关性及其相关的程度,探讨其内在机制,为制定综合防治计划提供科学依据。方法对155例调查个体进行腰椎骨密度(BMD)的定量CT测量,并通过填写完整的调查表了解被调查个体的一般情况、生活习惯及与心血管疾病有关的各种因子的详细情况,用多元逐步回归方法分析有关因素与骨密度之间的相关性。结果 (1)年龄、体重指数、饮酒、鸡蛋、总胆固醇、低密度脂蛋、尿蛋白均对人群BMD有影响;(2)影响男性BMD的危险因素有年龄、饮酒、鸡蛋、血钙、血磷、低密度脂蛋白、尿素氮、肌酐和尿蛋白,而影响女性BMD的危险因素是年龄、体重指数、高血压和总胆固醇值水平;(3)对人群BMD影响程度最大的因素依次是年龄、饮酒、血胆固醇和肌酐水平;对男性BMD影响最显著的因素依次是年龄、饮酒、血糖和尿素氮,而对女性BMD影响最为显著的因素是年龄、体重指数和总胆固醇水平;(4)得到3个BMD评估值的计算公式,综合反映了主要影响因素对BMD的综合作用。结论BMD与心血管病危险因素有密切关系,预防这些危险因素有同时防治心血管疾病和骨质疏松症的双重作用。更多还原

【Abstract】 Objective To investigate the correlation between the bone mineral density (BMD) and the risk factors of cardiovascular diseases, and analyze the probable mechanism of osteoporosis, providing the scientific data for the comprehensive prevention of both osteoporosis and cardiovascular diseasels. Methods 155 persons underwent quantitative CT of lumbar vertebrae for bone mineral density (BMD), and filled out interview sheet for the details of general condition, lifestyle and risk factors. The correlation between the BMD and risk factors was analyzed using multiple linear regression software. Results (1)The risk factors for BMD in males are age, drinking, milk intake, fracture, calcium, total cholesterol, blood urea nitrogen, creatinine, and urine protein, while the risk factors for females are age, body mass index and total cholesterol (P < 0.05) . (2) Multiple linear regression proved that age, drinking, total cholesterol, and creatinine influence BMD remarkably in both males and females, age, drinking, blood sugar, and blood urea nitrogen play an important role for BMD in males while age, body mass index, and total cholesterol for BMD in females. (3) Three formulae were used for roughly estimating the situation of BMD with scanned factors. Conclusions (1) The main factors for BMD in males are different from those for that in females. (2) Many risk factors of cardiovascular diseases such as age,obesity, hypertension, diabetes, high cholesterol influence BMD. (3) Drinking has effect on BMD. There are positive correlation between the BMD and the risk factors of cardiovascular diseases. Control of these risk factors can prevent cardiovascular disease as well as osteoporosis.更多还原