【摘要】 目的:探讨微血管密度(microvesseldensity,MVD)与腋窝淋巴结阴性乳腺癌(axillary-node-negativebreastcancer,ANNBC)预后的关系。方法:应用免疫组化方法检测ANNBC标本的MVD,并将所测值与部分预后指标的关系进行统计学分析。结果:MVD与ANNBC患者年龄、内分泌状况、激素水平无关(P均>0.05),而与ANNBC患者的无瘤生存率(disease-freesurvival,DFS)和总生存率(overallsurvival,OS)有明显关系(P分别=0.0012和0.0039)。结论:MVD是腋窝淋巴结阴性乳腺癌的独立预后因素,可以用于筛选高危患者进行综合辅助治疗。更多还原

【Abstract】 Objective: In this study, an attempt was made to explore correlations of microvessel density (MVD) with the prognosis of axillary-node-negative breast carcinoma(ANNBC). Methodes: Microvessel density was measured by an immunohistochemical technique. Results was analyzed by both univariate and multivariate statistical analysis to ensure the correlation of MVD with the clinical pathologic agents, disease-free survival and overall survival rates in patients with ANNBC. Results: MVD had no relevance with the clinical pathology factors(age, endocrine status and hormone receptor level), but it was apparently valuable in evaluating DFS and OS of ANNBC patients. Conclusion: Micro-vessel density is independent prognostic indicator of failure that is useful in selection of high-risk ANNBC patients for adjuvant therapies.更多还原