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长春瑞滨加奥沙利铂治疗晚期非小细胞肺癌的临床研究

Vinorelbine plus oxaliplatin in the treatment of 26 cases of advanced non-small cell lung cancer

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【作者】 丁健庄建生林新民胡冰季楚舒胡长路江丰收徐腾云陈曼萍孙玉蓓王刚

【Author】 DING Jian, ZHUANG Jian-sheng, LIN Xin-min, et al(Department of Oncology, Anhui Provincial Hospital, Hefei 230001,China)

【机构】 安徽省立医院肿瘤科安徽省立医院肿瘤科 合肥 230001合肥 230001合肥 230001

【摘要】 目的 观察长春瑞滨(Vinorelbine,商品名:盖诺)加奥沙利铂(Oxaliplatin,商品名:艾恒)联合化疗治疗晚期非小细胞肺癌(NSCLC)的临床效果和毒副反应。方法 26例晚期非小细胞肺癌患者采用盖诺25 mg/m2静脉推注,第1、8天;艾恒.130 mg/m2,静脉滴注4 h,第1天,21-28 d重复。结果 全组部分缓解(PR)9例,稳定(SD)12例,进展(PD)5例,总有效率(RR)为34.6%。主要毒副反应为骨髓抑制(Ⅲ-Ⅳ度白细胞减少发生率为42.3%)、神经毒性(80.8%)及恶心呕吐(42.3%)等。结论 长春瑞滨加奥沙利铂联合化疗方案治疗晚期非小细胞肺癌的疗效较高,耐受性好,值得临床进一步研究。

【Abstract】 Objective To evaluate the efficacy and safety of vinorelbine plus oxaliplatin in treatment of advanced non-small cell lung cancer (NSCLC) .Methods Twenty-six patients with NSCLC entered the study.The chemotherapy regimen consisted of vinorelbine 25 mg/m2 iv injection on days 1 and 8, oxaliplatin 130 mg/m2 iv infusion for 4 hours on day 1, repeated every 21-28 days. Results There were 9 partial response, 12 stable disease and 5 progression of disease, with the response rate being 34.6% . The major adverse effects were myelosuppression grade 3-4 occurring in 11 patients (42.3 % ) , neuro- sensory toxicity and vomiting observed in 80.8 % and 42.3 % of the patients respectively. Conclusions The vinorelbine plus oxaliplatin combined chemotherapy is an effective regimen for advanced non-small cell lung cancer with tolerable toxicity and deserves further evaluation.

  • 【文献出处】 中国肿瘤临床与康复 ,Chinese Journal of Clinical Oncology and Rehabilitation , 编辑部邮箱 ,2004年05期
  • 【分类号】R734.2
  • 【被引频次】2
  • 【下载频次】53
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