【摘要】 目的 :明确针刺治疗抑郁症的临床疗效 ,探讨针刺抗抑郁作用的神经内分泌学机制。方法 :将 60例抑郁症患者随机分为针刺组和药物治疗对照组。针刺组针刺内关、太冲、三阴交等穴治疗4周 ,对照组口服帕氟西汀治疗 4周 ,在治疗前后分别作地塞米松抑制试验 (DST) ,并检测血浆皮质醇和促肾上腺皮质激素 (ACTH)的浓度。结果 :针刺治疗抑郁症愈显率约 73% ,且不良反应小 ;两组血浆皮质醇和ACTH浓度 ,在治疗前后差异均有显著性意义(P <0 0 5) ,而且其含量随临床症状的缓解趋于正常。结论 :针刺对抑郁症患者下丘脑 垂体 肾上腺 (HPA)轴的影响是状态依赖性的 ,即随着针刺疗效的出现 ,患者的HPA轴功能也逐步恢复正常。更多还原

【Abstract】 ObjectiveTo observe the clinical effectiveness of ac upuncture in the patient of depression, and explore the neuroendocrine mechanism of acupuncture in anti-depression. Methods60 cases of depres sion were randomly divided into acupuncture group and medication group. They wer e respectively treated by acupuncture at Neiguan (PC 6), Taichong (LR 3), Sanyin jiao (SP 6), and oral western medicine for 4 weeks. Dexamethasone suppression te st (DST) before and after treatment were made and then the plasma cortisone and corticotropin (ACTH) were determined. ResultsThe markedly effe ctive rate was 73% in the acupuncture group with a less reverse effect; there we re significant differences before and after treatment in the plasma cortisone an d ACTH levels in the two groups (all P<0 05), and their levels tend to norm al with alleviation of clinical symptoms. ConclusionAcupunctur e has a better therapeutic effect on depression and can markedly decrease plasma corticol and ACTH levels in the patient of depression.更多还原