【摘要】 目的 通过对超临界流体制备的阿莫西林缓释、黏附微囊的研究,探索一条制备微米级缓释药物微囊的新方法。方法以乙基纤维素为包囊材料、卡波谱为黏附材料,采用超临界流体增强溶液分散度法制备了阿莫西林微囊,并对药物的包合情况、微囊的载药量、平均粒径和释药度等进行了研究。结果 运用本方法制得了粒径小于10μm的微囊。结论 阿莫西林-乙基纤维素-卡波谱微囊具有明显的缓释作用,超临界流体增强溶液分散度法是制备药物微囊的可行性方法。更多还原

【Abstract】 OBJECTIVE To study the characteristics of amoxicillin-ethylcellulose-caibopol microcapsules prepared by supercritical fluid. METHODS Amoxicillin was microcapsuled by the solution enhanced dispersion by supercritical fluids (SEDS) process using ethylcellu-lose as coating material and carbopol as adhesive material. Its particle size, DSC thermogram, the content of drug and drug release were measured. RESULTS The particle sizes of microcapsules were less than 10 μm, and the mean particle size of this experiment was 2.85 fan. There was a significant difference of DSC thermograms between the mixture of amoxicillin-ethylcellulose-carbopol and the processed amoxicillin micro-capsules. CONCLUSION The processed amoxicillin microcapsule had the sustained-release capability. The SEDS process is a promising method to prepare drug microcapsules.更多还原