【摘要】 目的探讨T淋巴瘤侵袭蛋白(Tiam1)表达水平在判断胸腺瘤生物学特性中的作用,以对临床判断为Ⅱ期胸腺瘤者行进一步的生物学评价。为术后综合治疗提供依据。方法对82例术后临床分期为Ⅱ期的胸腺瘤患者进行随访观察,并利用Tiam1蛋白对肿瘤组织和瘤旁正常胸腺组织做免疫组织化学染色,与75例Ⅲ期胸腺瘤进行对照,做统计学分析。结果Ⅱ期胸腺瘤患者12%术后复发,呈现恶性肿瘤生物学特性。总体上,Ⅱ期胸腺瘤组织内Tiam1蛋白表达与瘤旁正常胸腺无差异,而术后复发者差异有显著意义(P<0.05)。结论临床分期为Ⅱ期的胸腺瘤患者,部分呈现恶性肿瘤的表现,Tiam1蛋白对判断其生物学特性有重要意义。更多还原

【Abstract】 Objective: To study the function of Tiam-1 in the judgment of biological feature of thymoma, to study the biological evaluation of patients with thymoma in clinical stage Ⅱ, and to support the postoperative synthetical therapy. Methods:We followed up and observed 82 postoperative cases of thymoma in clinical stage Ⅱ, as well as investigated the expression of Tiam-1 protein with immunohistochemistry. Statistical analysis have been performed after comparison with the control group of 75 cases in clinical stage Ⅲ. Results: Of the cases in clinical stage Ⅱ, 12% were with recurrence and presented malignant neoplastic biological feature. Generally the level of Tiam-1 in cases in stage Ⅱ was similar to that in normal thymus tissue, but was significantly different with those cases with recurrence (P<0.05). Conclusion: Some of the cases in clinical stage Ⅱ present malignant neoplastic behavior, and Tiam-1 protein is crucial to the judgment of the biological features.更多还原