【摘要】 目的 :研究并评价盐酸川芎嗪脂质体的工艺及其质量。方法 :试验多种方法制备脂质体 ,考察主动载药与被动载药方法制备的脂质体的包封率。结果 :以主动载药制备方法中硫酸铵梯度法所得的脂质体包封率最高 ,达48.63 %;脂质体平均粒径为6.5μm ,经4℃～10℃贮放1mo稳定。结论 :用硫酸铵梯度法制备盐酸川芎嗪脂质体方法可行 ,可为开发盐酸川芎嗪新剂型提供实验依据。更多还原

【Abstract】 OBJECTIVE:To study the preparation of the ligustrazine hydrochloride liposome and evaluate its quality.METHODS:The liposome was prepared by various methods on a trial basis.The entrapped efficiency(EE)of the liposome derived from passive loading and active loading was compared.RESULTS:The ammonim sulfate gradient technology had the highest EE of 48.63%and its mean size was 6.5μm and the pH was 5.93.It was stable in refrigeratory(4℃～10℃)storage for 30 days.CONCLUSION:The ammonim sulfate gradient technology of preparation of the ligustrazine hydrochloride liposome is feasible.更多还原