【摘要】 目的探讨对脑血管病后伴有焦虑、抑郁症状者 ,是否合并抗抑郁剂 ,及合并不同抗抑郁剂对神经功能恢复 ,及焦虑、抑郁症状的疗效。方法对 90例患者随机分为三组 ,完成观察治疗者 83例 ,赛乐特组 2 9例 ,丙米嗪组 2 7例 ,对照组 2 7例。对三组患者均在治疗前及治疗后 2、4、8、12周测定HAMA、HAMD、CNS及MBI。结果赛乐特与丙米嗪对焦虑、抑郁症状有效率为 86.6%及 85 .1%,明显优于安慰剂组自然缓解率 44 .4%,赛乐特、丙米嗪和对照组神经功能恢复的有效率分别为 89.6%,70 .3 %,5 5 .5 %(赛乐特组与对照组比较P <0 .0 1,丙米嗪组与对照组比较P >0 .0 5 )。结论对脑血管病后伴有焦虑、抑郁症状者需合并抗抑郁剂治疗 ,赛乐特与丙米嗪抗焦虑、抑郁疗效相同 ,前者副作用小 ,依从性好 ,对神经功能恢复效更佳。更多还原

【Abstract】 Objective To investigate the effect of whether applied anti-depressive disorder drugs or the different types of these medicines on the improvement of neurological function and anxiety as well as depressive disorders after cerebrovascular diseases. Methods Ninety patients were divided randomized into three groups, among them,83 cases followed up visit. Seroxat grope were 29 cases. Imipramine grope were 27 cases. Control grope were 27 cases. HAMA, HAMD,CNS and MBI were used to evaluate for all patients on 2weeks, 4 weeks, 8 weeks and 12 weeks.Results The effects of improvement of the anxiety and depressive disorders were similar in seroxat group vs imipramine group. The validity rates were 86.2% and 85.1% ,respectively. These were much higher than the natural remission rate44.4% of control group. The validity rates of recovery on the neurological functions were 89.6%, 70.3% and 55.5% respectively in three groups ( P <0.01 in seroxat group vs control group, P >0.05 in imipramine group vs control group).Conclusions The anti-depressive disorder agents should be given to the patients after cerebrovascular diseases. The therapy effects of both seroxat and imipramine re similar, but the side effects are fewer and the compliance is better in the former medicine. The results indicated that seroxat is the better choice for the improvement of neurological function.[更多还原