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肝癌中幽门螺杆菌CagA~+亚型菌株的感染

Helicobacter pylori CagA~+ subtype strains infection in patients with liver cancer Department of laboratory medicine

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【作者】 雷秀霞; 陈小辉; 徐邦牢;

【Author】 LEI Xiu-xia,CHEN Xiao-hui,XU Bang-lao (The First Municipal People’s Hospital of Guangzhou,Guangzhou 510180,China)

【机构】 广州市第一人民医院检验科; 广州市第一人民医院检验科 广东广州510180; 广东广州510180; 广东广州510180;

【摘要】 目的 :探讨肝癌与H pylori感染的相关性。方法 :采用金标免疫斑点法和酶免疫检测法 (EIA)分别检测 33例肝癌患者及 16 9例普通成人Hp Ab和CagA Hp IgG抗体。 结果 :肝癌组Hp Ab和CagA+ Hp IgG检出率分别为 78 8%和 4 5 5 % ,而普通成人组分别为 5 5 0 %和 2 7 2 % ,经 χ2 检验 ,P <0 0 5 ,差异均有显著性。结论 :肝癌患者由于整体免疫力低下 ,易受H pylori感染。

【Abstract】 Objective: To investigate the relationship between liver cancer and Helicobacter pylori ( H.pylori ) infection.Methods:Hp-Ab and CagA-Hp-IgG in 33 patients with liver cancer and 169 normal people were respectively measured with colloid gold immunospot and EIA.Results:Positive ratios of Hp-Ab and CagA +-Hp-IgG in liver cancer and control group are 78.8% and 45.5%,55.0% and 27.2%,respectively.There was significance between them by χ 2 test.Conclusion:Patients with liver cancer were liable to be infected by H.pylori .

  • 【文献出处】 中国微生态学杂志 ,Chinese Journal of Microecology , 编辑部邮箱 ,2004年03期
  • 【分类号】R735.7
  • 【被引频次】3
  • 【下载频次】50
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