【摘要】 目的 :观察新一代甘草酸制剂甘草酸二铵脂质配位体 (DGLL)对酒精性脂肪肝的治疗作用。方法 :用连续灌服 (IG)酒精的方法建立大鼠酒精性脂肪肝模型 ,造模成功后给予药物治疗 ,以多烯磷脂酰胆碱(PPC)为对照 ,观察一般情况及测定血清肝功能指标和血脂参数 ,并对大鼠肝脏行病理学检查。结果 :连续灌服(IG)酒精 5周后大鼠形成酒精性脂肪肝 ,给药 2周后 ,PPC与DGLL中剂量 ( 5 0 0mg/kg)组能显著降低血中门冬氨酸氨基转移酶 (AST)活性与肝中甘油三酯 (TG)、总胆固醇 (TC)含量 ,改善肝脏炎症活动度与脂肪性变 ,DGLL中剂量组还能显著降低血中TC、丙二醛 (MDA)含量。结论 :甘草酸二铵脂质配位体能改善酒精性脂肪肝大鼠体内脂质代谢 ,对酒精性脂肪肝具有一定的治疗作用。更多还原

【Abstract】 AIM:To study the therapeutic effect of Diammonium Glycyrrhizinate lipid ligand(DGLL) on alcoholic fatty liver.METHOD:Rat models of alcoholic fatty liver were induced by ig.alcohol continuously.After the models were established successfully,were provided DGLL and polyene phosphatidylcholine(PPC).Serum hepatic function indexes and lipid contents of both serum and liver tissue were measured according to the instruction of Test kits.Liver tissue was dyed with HE and histopathological changes in liver were observed under light microscope.RESULT:Rat models of alcoholic fatty liver were induced successfully after ig alcohol for 5 weeks.After treatment by DGLL and PPC for 2 weeks,the level of AST in the serum,triglycerides (TG ) and total cholesterol (TC) in liver of rats with alcohol fatty liver decreased significantly.Histopahological changes of liver were improved.Meanwhile, the level of serum TG、TC and MDA in DGLL middle dose-treated rats deceased significantly.CONCLUSION:Both DGLL and PPC improved fat metabolism in alcoholic fatty liver rats and possessed therapeutic effect on alcoholic fatty liver.更多还原