【摘要】 目的　了解高血压家系和非高血压家系后代中 ,胰岛素受体底物 1(IRS 1)基因多态性与血糖水平的关系。　方法　对大庆地区 184个高血压家系和 99个非高血压家系的第一代直系亲属及其配偶共 5 6 6人进行空腹血糖 (FPG)、胰岛素 (Ins)、甘油三酯 (TG)和纤维蛋白原 (Fib)测定 ,并采用PCR BslN1酶解法 ,检测IRS 1基因 972密码子多态性。　结果　 (1)高血压及非高血压家族的第一代直系亲属中 ,IRS 1基因Gly/Arg型频率差异不显著 (7 4 %∶5 1% ) ;(2 )多因素分析 ,排除年龄、性别影响后 ,FPG最高三分变量组 (5 35± 0 0 1)mmol/L比最低三分变量组 (4 19± 0 0 2 )mmol/L携带IRS 1基因Gly/Arg型明显增多 (OR =3 2 8)。再调整父母高血压家族史影响后结果相似。 　结论　IRS 1基因可能是大庆地区部分人群血糖升高的遗传因素之一 ,但与原发性高血压无关。更多还原

【Abstract】 Objective To investigate the relationship between IRS-1 gene polymorphism and plasma glucose level. Methods 56 6 individuals in the present study were the first generation relatives and their spouses of 184 hypertensive families and 99 families with normal blood pressure . Fasting levels of plasma glucose, insulin, triglyceride and fibrinogen were de termined. The polymorphism of IRS-1 gene was determined by PCR/BslN1 digestion. Results (1) The frequency of Gly/Arg genotype of IRS-1 gene was not different in subjects with or without family history of hypertension. (2 ) After adjusting age, sex and BMI the frequencies of Gly/Arg genotypes were sig nificantly higher in the highest FPG-Tertile [FPG (5.35±0.01) mmol/L] than in the lowest FPG-Tertile [FPG (4.19±0.02) mmol/L], the OR was 3.28. Conclusions The genotype of Gly/Arg in IRS-1 gene is related with a higher plasma glucose level in these non-diabetic population, which suggests it may be one of the genetic factors contributing to the development of diabete s in population in Da-qing更多还原