【摘要】 目的　总结复发性卵巢未成熟畸胎瘤的特点 ,以及复发后手术和化疗的经验。方法　对 1 94 9～ 2 0 0 1年北京协和医院 34例复发性卵巢未成熟畸胎瘤进行回顾性分析。结果　去除 5例复发后仅行活检者 ,其余 2 9例随访中位数时间 84个月 (1 1～ 2 86个月 ) ,2 8例存活 (96 7%)。复发后手术病理级别为 0级共 2 3例次 ,1 7例次未再复发 ,未复发的患者中 9例次术后未化疗 ,其余 8例次接受 1～ 8个疗程化疗。复发后手术病理级别为 1～ 3级共 1 7例次。 9例次未再复发 ,均接受方案为VAC(长春新碱、环磷酰胺、阿霉素 )≥ 4个疗程或顺铂 (DDP)为主的联合化疗≥ 3个疗程。结论　复发性卵巢未成熟畸胎瘤的治疗效果是很好的。理想的再次肿瘤细胞减灭术非常重要 ,复发后病理级别未转为 0级者应辅以规范有效的化疗 (DDP为主的联合化疗至少 3个疗程 )。 0级畸胎瘤可以不化疗 ,但仍有增长可能 ,应密切随诊 ,延长随诊时间 ,积极手术。更多还原

【Abstract】 Objective To summarize the characteristics of recurrent ovarian immature teratoma,and the experience in surgery and chemotherapy.Methods 34 patients with recurrent ovarian immature teratoma were enrolled in the study,between 1949～2001.Results 5 cases of recurrence were removed from our analysis who were only performed biopsy.Among the rest 29 cases,28 survived,the survival rate being 96 7%.There were 23 cases whose pathological grade were 0 after second cytoreductive operation,and among them,17 hadn’t relapsed later and 9 were not given chemotherapy.There were 17 cases whose pathological grade were 1～3,and among them 9 hadn’t relapsed and received vincristine,actinomycin,and cyclophosphamide(VAC)≥4 courses or(cisplatin)DDP-based chemotherapy≥3 courses.Conclusion The treatment of recurrent ovarian immature teratoma is effective.Ideal second cytoreductive operation and more than 3 courses DDP-based chemotherapy are equally important for cases with grade 1～3.For grade 0,postoperation chemotherapy is not necessary.But for fear of the growing of teratoma,long time follow-up is needed.更多还原