【摘要】 目的　分析宫颈癌组织染色体微卫星不稳定性与人乳头瘤病毒 (HPV)感染状态并探讨其与临床病理参数的关系。方法　 2 0 0 1年 7月至 2 0 0 3年 1月中国医科大学第二临床学院及辽宁省肿瘤医院应用PCR 聚丙烯酰胺凝胶 硝酸银银染技术 ,检测 6 0例宫颈癌组织 3p染色体 3个位点微卫星不稳定性与HPV感染状态。结果　 2 3例宫颈癌组织存在微卫星不稳定 (38 3% ) ,微卫星不稳定性与分期、组织学类型及病理分级有关 ,与HPV感染无关。结论　微卫星不稳定性是一个独立于HPV感染之外的因素 ,在宫颈癌尤其腺癌的发展过程中起重要作用 ,并与宫颈癌预后有关更多还原

【Abstract】 Objective To investigate the microsatellite instability(MI) on chromosome 3p and infection of HPV and also to analyze the relationship between them and the clinicopathological characteristics in cervical carcinoma.Methods MI with 3 polymorphic markers on chromosome 3p and infection of HPV in 60 patients with cervical carcinoma were screened by polymerase chain reaction polyacrylamide gel silver stain method.Results MI was found in 23 patients(38 3%),which was not correlated with infection of HPV,however,it was associated with FIGO stage,histologic type and grade of the tumor.Conclusion Microsatellite instability may play an important role in the development of cervical carcinoma,especially in adenocarcinoma,but it is not linked to infection of HPV.It may be related to the prognosis.更多还原