【摘要】 目的　观察阿司匹林对高脂饮食大鼠胰岛素敏感性的影响。方法　灌服阿司匹林前后采用腹腔注射胰岛素耐量试验 (IITT)观察大鼠胰岛素的敏感性 ,并测定空服胰岛素、血糖和血脂等。结果　高脂饮食 4月、阿司匹林治疗 4周后 ,IITT发现高脂组腹腔注射胰岛素后 1h、1 5h和 2h的血糖及空腹胰岛素和甘油三酯水平显著高于正常对照组 (P <0 0 5或P <0 0 1 ) ;而阿司匹林治疗组腹腔注射胰岛素后 1h、1 5h和 2h的血糖及空腹胰岛素和甘油三酯水平显著低于高脂组 (P <0 0 5或P <0 0 1 ) ,与正常对照组差异无显著性。结论　大剂量阿司匹林有增加胰岛素敏感性和改善脂代谢紊乱的作用更多还原

【Abstract】 Objective To observe the effects of aspirin on insulin sensitivity in high fat fed rats. Methods Before and after ingesting aspirin, intraperitoneal insulin tolerance test was used to measure the insulin sensitivity, and fasting blood glucose, insulin and blood lipid were determined. Results Fat fed rats had similar glucose concentration to chow fed rats, but significantly higher levels of insulin, triglyceride(TG) and 1 h,1 5 h,2 h blood glucose concentration after intraperitoneal insulin tolerance test. Serum levels of insulin,TG and 1 h,1 5 h,2 h blood glucose concentration after intraperitoneal insulin tolerance test of fat fed rats treated with aspirin were significantly lowered. Conclusion It is confirmed that aspirin could raise insulin sensitivity of high fat fed rats.更多还原