【摘要】 为了考核甲型肝炎 (甲肝 )减毒活疫苗 (LA 1株 )的流行病学效果 ,于 1996年 12月以广西壮族自治区柳城县1～ 12岁儿童 7 6万人为观察对象 ,进行随机、双盲、对照实验。观察对象按个体出生月份单、双随机分为甲肝减毒活疫苗接种组和对照组 ,疫苗组接种 1ml,滴度为 10 6 5TCID50 的甲肝减毒活疫苗 ,对照组注射 1针伤寒Vi多糖疫苗 ,外对照组不做任何处理。结果显示 :在 5年的随访中 ,对照组和外对照组出现甲肝 38例 ,累积发病率 6 2 79/ 10万 ,疫苗接种组出现甲肝 1例 ,累积发病率 6 34/ 10万 ,两组发病率差异有显著的统计学意义。疫苗保护率为89 90 % ,95 %可信限为 6 9 86 %～ 10 0 0 0 %。表明规范化 ( 10 6 5TCID50 /ml)甲肝减毒活疫苗 (LA 1株 ) 5年的流行病学效果良好更多还原

【Abstract】 For evaluating the epidemiological effictivity of live attenuated hepatitis A vaccine(LA-strain),in Dec 1996,76,000 children of 1～12 years old in Liucheng county of Guangxi Zhuangzu Autonomous Region were enrolled in this study and they were randomly divided into 3 groups(the vaccine group?the control group and the external group, according to the months they were born.Children in the vaccine group were given one dose of 10 6 5 TCID 50 /ml live attenuated hepatitis A vaccine,those in the external group were given one dose of Vi polysaccharide typhoid vaccine and in the control group were given nothing In the 5 years of follow up,there were 38 hepatitis A cases found in the control group and the external group, the incidence was 62 79 per 100,000 population There was only one hepatitis A case in the vaccine group and the incidence was 6 34 per 100,000 population The difference of the incidence between the vaccine group and the control groups was highly significant(P<0 05) The protective efficacy of the vaccine was 89 90%(95%CI:69 86%～100 00%) We concluded that giving one dose(10 6 5 TCID 50 /ml)of standardized attenuated live hepatitis A vaccine(LA-strain),the epidemiological effictivity after 5 years was good.更多还原