【摘要】 目的观察血卟啉单甲醚光动力学疗法辅助手术治疗脑胶质瘤的近期疗效和随访效果。方法1999～2001年,应用光动力学疗法辅助手术治疗脑胶质瘤34例。术中暴露肿瘤前,静脉推注血卟啉单甲醚5mg/kg,显微镜下切除肿瘤后,以能量密度200J/cm2He-Ne激光照射肿瘤残腔。术后避光3d,观察近期临床表现,出院后定期随访2～4年。结果大部分患者术后临床症状缓解或消失;出院时Karnofsky记分升高者28例,无变化者6例,改善率82.4%(28/34);全部病例无皮肤光敏反应;术后1年生存率为76.5%(26/34);术后2年生存率为52.9%。结论激光光动力学疗法是一种有效的脑胶质瘤辅助治疗方法,近期临床效果满意,有利于提高生存率和生存质量,延长患者生命。更多还原

【Abstract】 Objective To report the technique and follow up effect of treating 34 patients diagnosed with glioma by combination of photodynamic therapy using hematoporphyrin monomethyl ether and operation Methods A total of 34 patients were given the photodynamic therapy in the operation The photosensitizer was infused into the vein of the patient(5mg/kg) at 3h before exposing the tumor The laser irradiated the tumor′s cavity for killing these survival tumor cells after resecting the tumor under the microscopy(200J/cm2) The patients who underwent tumor resection combined with PDT were followed up Results In this group, the skin phototoxic reaction wasn′t observed, the rate of amelioration of postoperative Karnofsky score was 82 4%,the 1 year survival rate of these 34 patients with malignant gliomas (WHO Ⅲ Ⅳ) was 76 5%,but the 2 year survival rate was 52 9% Conclusions All the results indicate that photodynamic therapy is an effective assistant approach for treating gliomas. It is necessary for improving effect and patients′life quality.更多还原