【摘要】 目的　研究长期饮酒对男性生殖系统功能的损伤。方法　选择 4 5名长期饮酒者和 9名慢性酒精中毒者为实验组 ,2 0名不饮酒者为对照组 ,检测精液质量 ,血清中睾酮 (T)、雌二醇 (E2 )、黄体生成素 (LH)和促卵泡素 (FSH)的水平及血清、精浆和精子中乳酸脱氢酶 (LDH)、乳酸脱氢酶同工酶 -x(LDH -x)、葡萄糖 - 6磷酸脱氢酶 (G - 6PD)、葡萄糖苷醛酸酶 (β -G)活力。结果　饮酒达 10年以上 ,饮酒量为每日 10 0～ 15 0g 38℃白酒 ,每月饮 2 0次以上 ,其精子数、活动精子率、精子中的LDH -x活性均明显低于正常对照组 (均P <0 0 5 ) ,饮酒量为每日 15 0～ 2 5 0g 38℃白酒 ,每月饮 2 0次以上 ,血清中T下降 ,E2 、FSH、LH均升高 (均P <0 0 5或P <0 0 1) ,精浆和精子中的LDH、LDH -x、G - 6PD和 β -G活性均明显低于对照组 (均P <0 0 5 ) ,尤以LDH -x敏感。 结论　长期酗酒对男性生精功能、睾丸标志酶及生殖内分泌激素水平产生严重影响。更多还原

【Abstract】 Objective To study the functions damage of male reproductive system induced by drinking excessively.Methods One control group was 45 people who drink excessively,the other control group was 9 people poisoned by alcohol,and case group was 20 people without drinking.To detect the quality of semen,T,E\-2,LH and FSH in serum,LDH,LDH-x,G-6PD and β-G in serum,sermen and spermatozoa.Results Dinking 100-150?g of white spirit of 38 degree one day and above 20 times a month for over 10 years,the quantity of spermatozoa,the rate of activing spermatozoa,and the activity of LDH-x in sperimatozoa were lower than those of control group ( P <0.05).Drinking 150-250?g T in serum decreased,E\-2,LH,FSH increased ( P <0.05 or P <0.01),The activity of LDH,LDH-x,G-6PD,β-G in serum of semen were lower than those of control group obviously,especially LDH-x.Conclusion Drinking excessively influenced male spermatogenesis,teslis marker enzyme and gonadal hormone significally.更多还原