【摘要】 目的 :研究影响ⅢA期 N2非小细胞肺癌根治术后患者预后的因素。方法 :自 1995年 3月～ 1998年 2月在上海市胸科医院 118例非小细胞肺癌术后病理分期为ⅢA期 N2的患者 ,对可能影响其生存率的各种临床、病理、治疗方法等因素进行分析 ,用Kaplan Meier曲线及Logrank检验生存率差异 ,Cox单、多因素分析评价各因素对生存率的影响。结果 :118例ⅢA期 N2非小细胞肺癌患者的三年及五年生存率分别为 4 0 .5 %和 18.4 % ,肿瘤切除情况、N2淋巴结转移的个数和组数及术后化疗周期数均与生存率有关。在多因素分析中 ,N2淋巴结转移的个数及术后化疗周期数均为影响生存率的重要因素。结论 :N2淋巴结转移的个数及术后化疗周期数是影响ⅢA期 N2非小细胞肺癌预后的重要因素更多还原

【Abstract】 Purpose:To identify clinical predictors of stage ⅢA-N2 in patients with non-small cell lung cancer. Methods:From March 1995 to February 1998, 118 patients with pathological stage ⅢA-N2 non-small cell lung cancer who underwent a resection by Shanghai Chest Hospital were analysed. Prognostic factors were estimated from the date of operation using the Kaplan-Meier and log-rank analysis. The Cox regression model evaluated the influence of factors on the survival. Results:The overall of 3-year and 5-year survivals of the 118 patients were 40.5% and 18.4%. Margin, the number of N2 lymph nodes and stations, the cycles of adjuvant chemotherapy were associated with survival. In a multivariate analysis, the number of N2 lymph nodes and the cycles of adjuvant chemotherapy significantly influenced survival. Conclusions:The number of N2 lymph nodes and the cycles of adjuvant chemotherapy were important prognostic factors of stage ⅢA-N2 non-small cell lung cancer.更多还原