【摘要】 目的 :探讨胰腺实性假乳头状肿瘤的临床病理学特点及免疫表型。方法 :对 4例胰腺实性假乳头状肿瘤临床资料进行回顾性复习 ,并采用免疫组织化学EnVision法检测肿瘤细胞Vim、CK8、CK18、Chromogranin、Sy、AAT、NSE、S 10 0的表达。结果 :4例患者均为女性 ,平均年龄 30岁。肿瘤由乳头状和实性区混合构成 ,肿瘤细胞形态单一 ,免疫组化标记显示Vim。 4例均呈弥漫性强阳性 ;AAT灶性强阳性 ;NSE三例阳性 ,一例阴性 ;Sy、Chromo granin和S 10 0 4例均阴性 ;CK8和CK18一例散在弱阳性 ,另三例阴性。结论 :胰腺实性假乳头状肿瘤是一种好发于青年女性、具有低度恶性潜能的肿瘤 ,免疫组织化学对胰腺实性假乳头状肿瘤的诊断和鉴别诊断具有重要价值更多还原

【Abstract】 Purpose:To study clinical and pathological features of solid-pseudopapillary tumor(SPT) of the pancreas. Methods:The clinical data were reviewed in four patients with SPT. Immunohistochemistry for Vim, CK8, CK18, Chromogranin, Sy, AAT, NSE, S-100 was performed in all four cases using EnVision. Results:All four patients were female. The mean age was 30 years. The tumors were composed of papillary and solid structures. The uniform cells were strongly diffuse positive for Vim, and strongly positive for focal AAT in four cases. Three cases were positive for NSE. All four cases were negative for Sy , Chromogranin and S-100. One case was poorly positive for CK8 and CK18. Conclusions:SPT of the pancreas, preferentially in young women, is a tumor with low malignant potential. Immunohistochemistry is very important in the diagnosis and differential diagnosis of SPT of the pancreas..更多还原