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妊娠合并乙型肝炎宫内感染及对策
Preliminary research on inner uterus infection and the measures taken for pregnant women with B type hepatitis
【摘要】 目的:探讨乙肝孕妇的宫内感染率,减少新生儿产前受HBV的感染,提高接种疫苗后的免疫效果。方法:采用酶联免疫吸附实验(ELISA)法,测定妊娠4月的孕妇乙肝标记物阳性者(HBsAg阳性、HBeAg阳性)共61例,随机分为两组,在孕28周、32周、36周分别注射乙肝免疫球蛋白200 IU联合乙肝疫苗和单用乙肝疫苗进行对照,以评价HBV阻断效果。结果:联合免疫组宫内感染率为6.67%,单纯免疫组宫内感染率为19.33%,两组比较,有显著性差异;对宫内感染的8例婴幼儿实行乙肝疫苗和HBIG联合免疫,1年后HBsAg的阳性率为50.00%。结论:妊娠晚期多次注射HBIG确实能降低宫内感染率,对已发生宫内感染的婴幼儿采用联合免疫也具有一定的效果。
【Abstract】 Objective: To investigate the inner uterus infection rate of the pregnant women with B Type Hepatitis, reduce the HBV infection rate of the infants before delivery and raise the immune effect after inoculation. Methods: With ELISA, 61 4-month pregnant wemen whose B Type Hepatitis markers are positive (HbsAg+HbesAg+) are measured. They are divided into 2 groups randomly. During the 28th, 32ed, and 36th week, the participants of one of the group are injected B Type Hepatitis immune globin 200IU combined B Type Hepatitis vaccine and those of the other group are only injected B Type Hepatitis vaccine. The results are compared and the HBV interdiction effect is examined. Results: (1) The inner uterus infection rate of the group using combined B Type Hepatitis vaccine is 6.67%, the infection rate of the group using single immune method is 19.33%. There is significant difference between the results of the two groups. (2) A year after carrying out B Type Hepatitis vaccine and HbIg combined immune method for 8 infected infants, the HbsAg positive rate is 50%. Conclusion: It can reduce the inner uterus infection rate to inject HbsAg for many times. It also has curative effects for infants with inner uterus infection to use combined immune method.
【Key words】 Gestation complication; B Type Hepatitis; Inner utetus infection; Combined immunity;
- 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2004年10期
- 【分类号】R714.251
- 【被引频次】5
- 【下载频次】94