【摘要】 目的:探讨血清可溶性细胞间粘附分子-1(sICAM-1)在支气管哮喘患儿发病机制中的作用。方法:测定46例支气管哮喘患儿急性发作期血清sICAM-1的水平,其中有28例测定了恢复期血清sICAM-1的水平,同时以20例正常儿童血清sICAM-1作对照。结果:支气管哮喘患儿血清sICAM-1在急性期和缓解期均较正常对照组升高,差异有显著性(P<0.05);哮喘患儿重度发作较轻、中度发作升高更显著(P<0.01)。结论:sICAM-1参与了支气管哮喘的发病,可作为判断病情严重程度的重要指标之一。更多还原

【Abstract】 Objective: To evaluate the effect of soluble intercellular adhesion molecule -1 (sICAM-1) in pathogenesis of children with Bronchi asthma. Methods: Serum sICAM-1 was measured in 46 children with asthmatic acute attack, 28 children in asthmatic remission and 20 healthy controls. Results: The level of sICAM - 1 was greatly increased in asthmatic acute attack and remission period than health contrds (P<0. 05). the level was also greatly increased in sever asthmatic acute attacks than in mild or moderate attacks (P<0. 05) . Conclusion: We suggest that sICAM -1 may play a role in pathogenesis of children with asthma. It serves as an important index in judging the severity of bronchi asthma.更多还原