【摘要】 目的:探讨强迫症患者局部脑血流量(rCBF)特点。方法:对13例强迫症患者、19名正常对照者进行脑单光子发射计算机体层摄影体(SPECT)检查,并比较检查结果。结果:强迫症患者左颞枕叶SPECT放射性计数比值明显低于正常对照组(P<0.05);轻、重度强迫症患者左右两侧尾状核SPECT放射性计数比值差异有显著性(P<0.05);强迫症患者大脑皮层前额叶、额颞叶、颞前叶、颞枕叶、枕前叶等部位,左侧脑血流灌注低于右侧(P<0.01或P<0.05)。结论:强迫症患者可能存在颞叶、尾状核功能障碍,大脑皮层脑血流灌注明显不对称。更多还原

【Abstract】 Objective To study the characteristics of the regional cerebral blood flow(rCBF) in patients with obsessive-compulsive disorder(OCD). Methods Single photon emission computed-tomography (SPECT) was performed in 13 OCD patients and 19 normal subjects and the examination outcomes in the 2 groups were compared. Results The SPECT radioactive count ratio detected in left temporo-occipital lobe was lower in the OCD patients than that detected in the normal subjects(P<0.05).The difference of SPECT radioactive count ratio detected between left and right cerebral was significantly different between severe OCD patients and mild OCD patients in posterior caudate nucleus(P<0.05).The rCBF of left cortex was significantly lower than that of right cortex(P<0.05 orP<0.01). Conclusion There are functional disorders in temporal lobe and caudate nucleus in OCD patients, and the cerebral perfusion in cortex is obviously asymmetric.更多还原