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流式细胞仪检测结节性红斑结节性血管炎患者T细胞亚群
Flow Cytometric Dectection of T-cell subsets in Erythema Nodosum and Nodular Vasculitis Patients
【摘要】 目的 研究结节性红斑、结节性血管炎患者细胞免疫功能。方法 应用流式细胞仪技术 ,通过微量血直接免疫荧光染色法测定患者外周血T细胞亚群。结果 结节性红斑与结节性血管炎患者外周组CD3 + ,CD4+ 较对照组明显下降 (P <0 .0 5 ) ;CD8+ ,CD4+ /CD8+ 比值较对照组有所下降 ,但差异无显著性 (P >0 .0 5 )。结论 结节性红斑、结节性血管炎患者存在细胞免疫功能改变。
【Abstract】 Objective To study the role of cellular immunity in pathogenesis of erythema nodosum and nodular vasculitis.Methods T-lymphocyte subsets were measured by flow cytometry(FCM). Results Decrease of CD 3,CD 4 were found in patients group as compared with the controls.But,CD 8 and CD 4/CD 8 ratio in patients group were not different from that of the controls.Conclusion These results indicated cellular immunity was impaired in erythema nodosum and nodular vasculitis patients.
【关键词】 结节性红斑;
结节性血管炎;
T细胞亚群;
流式细胞仪;
【Key words】 Erythema nodosum; Nodular vasculitis; T-lymphocyte subsets; Flow cytometry;
【Key words】 Erythema nodosum; Nodular vasculitis; T-lymphocyte subsets; Flow cytometry;
- 【文献出处】 中国皮肤性病学杂志 ,The Chinese Journal of Dermatovenereology , 编辑部邮箱 ,2004年06期
- 【分类号】R758.6
- 【被引频次】9
- 【下载频次】151