【摘要】 目的 :探讨层粘连蛋白受体 (LN -R)和人血管Ⅷ因子相关抗原 (FⅧ -RAg)在胃癌中的表达和微血管密度(MVD)计数的意义。方法 :应用免疫组织化学S -P法检测 6 8例胃癌组织中LN -R和FⅧ -RAg的表达及MVD的计数并分析其意义。结果 :LN -R阳性表达和MVD计数与肿瘤分化水平、浸润深度 (P <0 .0 1)及淋巴结转移 (P<0 .0 0 1)密切相关。不同组织学类型中LN -R的表达具有显著相关性 (P <0 .0 1) ,而MVD与胃癌组织学类型无显著性差异 (P >0 .0 5 )。结论 :LN -R和FⅧ -RAg的高表达与肿瘤分化、侵袭和转移的关系十分密切。LN -R和FⅧ -RAg的检测及MVD计数可作为判断胃癌恶性程度和预后的重要生物学指标更多还原

【Abstract】 Objective To investigate the expression and significance of laminin receptor(LN-R)and human Factor Ⅷ-related antigen (FⅧ-RAg) in gastric carcinoma. Methods The LN-R expression and MVD were examined with immunohitochemical S-P methods in 68 cases of human gastric carcinoma tissues with LN-R and anti-human Factor Ⅷ-related antigen (FⅧ-RAg) antibody , and their significance was analyzed.Results The value of LN-R and MVD was related with differentiation level,depth of invasion ( P <0.01) and lymph node metastasis ( P <0.001). The expression of LN-R was related to the histologic types ( P <0.01), but MVD with relation to the histologic types of gastric carcinoma was not significant ( P >0.05). Conclusion These results suggest that higher expression of LN-R and FⅧ-RAg in gastric carcinoma were related with differentiation level,depth of invasion and metastasis. The expression of LN-R,FⅧ-RAg and MVD might be an important biological markers for predicting the degree of malignancy and prognosis of patient with gastric carcinoma.更多还原