【摘要】 目的　观察郁乐疏对卒中后抑郁 (PSD)大鼠脑内单胺递质的影响 ,探讨其抗抑郁作用机制。方法　采用线栓法制备局灶性脑缺血大鼠模型 ,在此基础上综合孤养、应激处理复合制备PSD大鼠模型。采用荧光分光度法测定大鼠双侧额顶皮层及脑干的单胺递质 (NA、5 -HT和DA)含量。观察郁乐疏对PSD大鼠脑内单胺递质的影响。结果　中、高剂量郁乐疏可显著增加PSD大鼠脑内的NA、5 -HT含量。结论　郁乐疏对PSD大鼠脑内单胺递质降低有显著的改善作用。其抗抑郁的主要作用机制与增加脑内单胺递质有关更多还原

【Abstract】 Objective To study the anti-depression mechanism by observing the affect of Yu Le Shu on monoamine transmitter in the brain of PSD hamster.Method making PSD hamster model of focal cerebral ischemia by means of thread -tightening the artery in the neck, followed by isolation feed and irritable stimuli; derterming the monoamine transmitter (NA, 5-HT and DA ) content in both frontoparietal cortex and in the brain stem by fluorospectrophotometry; observing the affect of Yu Le Shu on monoamine transmitter in the brain of PSD hamster.Result medium dosage or large dosage of Yu Le Shu can significantly help increase NA, 5-HT content in the brain of PSD hamster.Conclusion Yu Le Shu can considerably ameliorate the decreased monoamine transmitter in the brain of PSD hamster, whose primary anti-depression mechanism is related to the increase of monoamine transmitter in the brain.更多还原